We are glad to announce that PersonalizeAF has already started its journey. The official start date of PersonalizeAF project was dated on 1st of February, and we can say that we have work hard to prepare everything in the project for the next four years. Even if we have faced some difficulties because of the …
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Hospital admissions because of alcohol-related liver disease (ArLD) are increasing. The amount of alcohol consumed and pattern of drinking are linked to increased risk of ArLD. However, other factors such as obesity, co-existent liver disease – particularly hepatitis C, gender, nutritional status and genetic factors also play a role. The spectrum of ArLD ranges from …
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T cell activation and function require a structured engagement of antigen-presenting cells. These cell contacts are characterized by two distinct dynamics in vivo: transient contacts resulting from promigratory junctions called immunological kinapses or prolonged contacts from stable junctions called immunological synapses. Kinapses operate in the steady state to allow referencing to self-peptide-MHC (pMHC) and searching …
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Optimal protein synthesis requires bases in transfer RNAs to be modified. A key modification has been shown to involve an unusual two-step mechanism that entails the sequential activities of two enzymes. A central dogma of molecular biology is that DNA and the corresponding RNA are complementary. But this complementarity is rewired by a process called …
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Cancer incidence and mortality statistics reported by the American Cancer Society1 and other resources were used to create the list. To qualify as a common cancer for the list, the estimated annual incidence for 2019 had to be 40,000 cases or more. The most common type of cancer on the list is breast cancer, with 271,270 …
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Jaundice, also known as icterus, is a yellowing of the skin, whites of the eyes, and body fluids due to an increase in the amount of bilirubin in the blood. Bilirubin is a yellowish pigment and byproduct of the natural daily breakdown of red blood cells (RBCs). Red blood cells typically survive for about 120 …
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Patients with liver disease often require drug therapy. Because the liver is the main site of drug detoxification and elimination, each patient’s need for therapy must be carefully assessed; the choice of drug, its dose and the duration of therapy must be carefully considered to avoid adverse effects. Ideally, one should choose a drug that …
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