Inducing fibrillation episodes ex vivo Hi there! As I mentioned in my last post, this post will be dedicated to inducing atrial fibrillation in tissue culture. If we think about the “macro” triggers which increase the predisposition for fibrillating episodes to happen, this can be due to several risk factors such as comorbidities, emotional triggers …
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Arrhythmic behaviour: single-cell vs tissue level Hi everyone! It’s been a while. This start of the year has been quite busy between starting new collaborations, experiments, analysis and presentations. I can’t complain though, there are many exciting things in queue! My last post was about cardiac electro-mechanics and some introduction to slice culture. I left …
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Exploring atrial electro-mechanics This past month I took it easier with experiments as we had a three-week workshop, which in normal condition would have seen all personalizeAF ESRs gathered in Valencia. As you may guess, none of us had the chance to travel there. Nevertheless, I have to say that we were pretty good at …
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Myostretching with a view! View from the lab in Amsterdam. In healthy conditions the heart experiences several mechanical changes. Let’s just think about the pressure that the blood exert on the cardiac walls when it enters each chamber, or when it contracts to eject the blood in the systemic flow. When a pathological condition occurs, …
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A Tour de Force for Atrial Cells Introducing you to cell isolation, calcium handling and the magic of life. These last two months have been crazy busy with experiments. The project I am working on right now aims at investigating local calcium releases, events called “calcium sparks”, after fast electrical stimulation of atrial cells to …
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The fibrillating beginning of my journey Universitätsbibliothek of Freiburg from the Synagogenplatz. It is crazy how time flies, one moment I was living under lockdown due to covid-19, and the next I am in Freiburg (Germany), starting a new experience and a new life. As you may know from my presentation on the personalizeAF website, …
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